Whole blood and serum concentrations of metals in a Swedish population-based sample.
نویسندگان
چکیده
OBJECTIVE While the potential toxicity of metals in humans is a well-established field of research, there are few studies that examine circulating concentrations of metals in large population-based samples. The aim of this study was to analyze levels of heavy metals and trace elements in both whole blood and serum in an elderly population, and to examine if gender, kidney function, haemoglobin or serum albumin could impact the distribution of metals between whole blood and serum. METHODS Whole blood and serum samples from 1016 70-year-olds living in Uppsala, Sweden, were analyzed for aluminium, cadmium, cobalt, copper, chromium, mercury, manganese, molybdenum, nickel, lead, and zinc using inductively coupled plasma-sector field mass spectrometry (ICP-SFMS). Distribution between whole blood and serum was evaluated by the ratio between whole blood and serum concentration (B/S-ratio). RESULTS Concentrations differed significantly between whole blood and serum measurements for all 11 metals (p < 0.00001). The highest B/S-ratios were found for lead (27), zinc (9), manganese (6), and nickel (4). Copper (0.86), cobalt (0.84), and molybdenum (0.86) showed B/S-ratios < 1. Especially the B/S-ratios for chromium, mercury and nickel correlated with kidney function (GFR) (r = 0.21, - 0.21 and - 0.36 respectively, p < 0.0001). CONCLUSIONS The distribution between whole blood and serum varied considerably for different metals. This distribution correlated with physiological factors, mainly with kidney function, for several of the metals.
منابع مشابه
P-41: Investigation of Correlation be tween Zinc, Copper and Iron Concentrations in Blood Serum, Testicular Tissue and Epididymal Tissue of Rams and their Associations with Serum Luteinizing Hormone Concentration
Background Correlation between metals may be useful in predicting toxicity to various biologically important organisms. The purpose of the current analysis was to evaluate the association of levels zinc, copper and iron in the ram blood serum, testicular tissue and epididymal tissue, and correlations of these elements to luteinizing hormone were investigated. MaterialsAndMethods Testis and bloo...
متن کاملRelationship between Immunoglobulin Concentrations in the Ewe's Serum and Colostrum, and Lamb's Serum in Lori-Bakhtiari Sheep
In this study 71 head of conceiving ewe and their progeny (91 head) from the flock of Lori-Bakhtiari sheep (360 head), in Sholi Station were randomly selected to determine the relationship between the immunoglobulin (IgG) concentration in the ewe's serum and colostrum, and lamb's serum. Ewe blood sample, colostrum of ewe and blood of the lamb was taken 2 weeks before parturition, 1 to 8 hours a...
متن کاملSerum and whole blood Selenium in children with Atopic Dermatitis: A case-control study
Background and aim: Atopic dermatitis (AD) is a chronic, inflammatory, pruritic skin disease usually observed in patients with other allergies. Decreased selenium levels and improvement with selenium supplement are reported in AD. The aim of this study was to compare serum and whole blood selenium in children with AD and control group.Materials and Methods: In an age-se...
متن کاملAssociations of Breast Milk Mercury, Lead and Cadmium Concentrations with Hyperthyrotropinemia in Neonates during the First Few Days after Birth
Introduction: Recent studies show that exposure to heavy metals can affect thyroid function. This study aimed to assess heavy metals in breast milk during the first few days postpartum and their relationships with hyperthyrotropinemia in neonates. Materials and Methods: In this case-control study, 82 mother-infant pairs, consisting of 21 pairs (neonates with hyperthyrotropinemia) in the case gr...
متن کاملبررسی ارتباط سطح سرمی 25 هیدروکسی ویتامین - D با عوامل خطر ساز سندرم متابولیک در پزشکان شهر زنجان
Background and Objective: Previous studies indicate an inverse association of serum 25-hydroxyvitamin-D level with obesity, metabolic syndrome and cardiovascular events. This study was aimed to assess metabolic syndrome correlation with serum Vit-D levels of physicians in Zanjan city (Iran). Materials and Methods: In an analytical cross-sectional study, a total of 108 physicians were selected a...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Scandinavian journal of clinical and laboratory investigation
دوره 74 2 شماره
صفحات -
تاریخ انتشار 2014